Synthesis of the chlorofusin cyclic peptide
نویسندگان
چکیده
منابع مشابه
Solid-phase synthesis of chlorofusin analogues.
We report an efficient and versatile solid-phase synthesis through which two series of chlorofusin analogues, one bearing varying chromophores and the other with various amino acid substitutions in the cyclic peptide, were synthesized. These peptides were prepared using a strategy involving side-chain immobilization, on-resin cyclization, and postcyclization modification. The success of these s...
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heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...
15 صفحه اولTotal synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.
Chlorofusin (1, Figure 1A) was isolated from the fungal strain Microdochium caespitosum and found to disrupt the MDM2-p53 interaction by binding to the N-terminal domain of MDM2.1 As such, chlorofusin represents an exciting lead for antineoplastic intervention that acts by a rare disruption of a protein-protein interaction.2 On the basis of spectroscopic and degradation studies, the structure w...
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While tremendous efforts have been made in investigating scalable approaches for fabricating nanoparticles, less progress has been made in scalable synthesis of cyclic peptide nanoparticles and nanotubes, despite their great potential for broader biomedical applications. In this paper, tunable synthesis of self-assembled cyclic peptide nanotubes and nanoparticles using three different methods, ...
متن کاملEpisulfonium ion-mediated cyclic peptide and triazine synthesis.
The product of an episulfonium ion-mediated cyclotrimerisation, previously reported as being a 15-membered ring trilactam, has now been shown to be a 1,3,5-triazine. Smaller medium-ring bilactams have, however, been synthesised from linear precursors using the sulfur-based methodology.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2009
ISSN: 0040-4020
DOI: 10.1016/j.tet.2008.09.029